Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA) (2024)

(2024). Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA). European Journal of Surgical Oncology, 50(6), Artículo 107983. https://doi.org/10.1016/j.ejso.2024.107983

et al. / Predictors of anastomotic leak and conduit necrosis after oesophagectomy : Results from the oesophago-gastric anastomosis audit (OGAA). En: European Journal of Surgical Oncology. 2024 ; Vol. 50, N.º 6.

@article{ef1dee0379c64c7ca73bd79779b91414,

title = "Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA)",

abstract = "Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to generate a risk scoring model for AL and CN after oesophagectomy. Methods: Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018–December 2018. Definitions for AL and CN were those set out by the Oesophageal Complications Consensus Group. Univariate and multivariate analyses were performed to identify risk factors for both AL and CN. A risk score was then produced for both AL and CN using the derivation set, then internally validated using the validation set. Results: This study included 2247 oesophagectomies across 137 hospitals in 41 countries. The AL rate was 14.2% and CN rate was 2.7%. Preoperative factors that were independent predictors of AL were cardiovascular comorbidity and chronic obstructive pulmonary disease. The risk scoring model showed insufficient predictive ability in internal validation (area under the receiver-operating-characteristic curve [AUROC] = 0.618). Preoperative factors that were independent predictors of CN were: body mass index, Eastern Cooperative Oncology Group performance status, previous myocardial infarction and smoking history. These were converted into a risk-scoring model and internally validated using the validation set with an AUROC of 0.775. Conclusion: Despite a large dataset, AL proves difficult to predict using preoperative factors. The risk-scoring model for CN provides an internally validated tool to estimate a patient's risk preoperatively.",

author = "Griffiths, {Ewen A.} and Halle-Smith, {J. M.} and Kamarajah, {S. K.} and Evans, {R. P.T.} and D. Nepogodiev and J. Hodson and Bundred, {J. R.} and I. Gockel and Gossage, {J. A.} and A. Isik and Kauppila, {J. H.} and B. Kidane and Mahendran, {H. A.} and I. Negoi and Okonta, {K. E.} and R. Sayyed and {van Hillegersberg}, R. and Vohra, {R. S.} and Wijnhoven, {B. P.L.} and P. Singh and Griffiths, {E. A.} and D. Alderson and J. Bundred and J. Gossage and B. Jefferies and S. McKay and I. Mohamed and {Siaw- Acheampong}, K. and R. Vohra and K. Wanigasooriya and T. Whitehouse and A. Gjata and Moreno, {J. I.} and Takeda, {F. R.} and {Guevara Castro}, R. and A. Bekele and T. Harustiak and A. Kechagias and A. Bagajevas and A. Kennedy and {Da Roit}, A. and Azagra, {J. S.} and L. Mej{\'i}a-Fern{\'a}ndez and {El Kafsi}, J. and Sayyed, {R. H.} and M. Sousa and Sampaio, {A. S.} and R. Blanco and B. Wallner and A. Isaza-Restrepo",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology",

year = "2024",

month = jun,

doi = "10.1016/j.ejso.2024.107983",

language = "English (US)",

volume = "50",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

publisher = "W.B. Saunders Ltd",

number = "6",

}

2024, 'Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA)', European Journal of Surgical Oncology, vol. 50, n.º 6, 107983. https://doi.org/10.1016/j.ejso.2024.107983

Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA). / et al.
En: European Journal of Surgical Oncology, Vol. 50, N.º 6, 107983, 06.2024.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Predictors of anastomotic leak and conduit necrosis after oesophagectomy

T2 - Results from the oesophago-gastric anastomosis audit (OGAA)

AU - Griffiths, Ewen A.

AU - Halle-Smith, J. M.

AU - Kamarajah, S. K.

AU - Evans, R. P.T.

AU - Nepogodiev, D.

AU - Hodson, J.

AU - Bundred, J. R.

AU - Gockel, I.

AU - Gossage, J. A.

AU - Isik, A.

AU - Kauppila, J. H.

AU - Kidane, B.

AU - Mahendran, H. A.

AU - Negoi, I.

AU - Okonta, K. E.

AU - Sayyed, R.

AU - van Hillegersberg, R.

AU - Vohra, R. S.

AU - Wijnhoven, B. P.L.

AU - Singh, P.

AU - Griffiths, E. A.

AU - Alderson, D.

AU - Bundred, J.

AU - Gossage, J.

AU - Jefferies, B.

AU - McKay, S.

AU - Mohamed, I.

AU - Siaw- Acheampong, K.

AU - Vohra, R.

AU - Wanigasooriya, K.

AU - Whitehouse, T.

AU - Gjata, A.

AU - Moreno, J. I.

AU - Takeda, F. R.

AU - Guevara Castro, R.

AU - Bekele, A.

AU - Harustiak, T.

AU - Kechagias, A.

AU - Bagajevas, A.

AU - Kennedy, A.

AU - Da Roit, A.

AU - Azagra, J. S.

AU - Mejía-Fernández, L.

AU - El Kafsi, J.

AU - Sayyed, R. H.

AU - Sousa, M.

AU - Sampaio, A. S.

AU - Blanco, R.

AU - Wallner, B.

AU - Isaza-Restrepo, A.

N1 - Publisher Copyright:© 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology

PY - 2024/6

Y1 - 2024/6

N2 - Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to generate a risk scoring model for AL and CN after oesophagectomy. Methods: Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018–December 2018. Definitions for AL and CN were those set out by the Oesophageal Complications Consensus Group. Univariate and multivariate analyses were performed to identify risk factors for both AL and CN. A risk score was then produced for both AL and CN using the derivation set, then internally validated using the validation set. Results: This study included 2247 oesophagectomies across 137 hospitals in 41 countries. The AL rate was 14.2% and CN rate was 2.7%. Preoperative factors that were independent predictors of AL were cardiovascular comorbidity and chronic obstructive pulmonary disease. The risk scoring model showed insufficient predictive ability in internal validation (area under the receiver-operating-characteristic curve [AUROC] = 0.618). Preoperative factors that were independent predictors of CN were: body mass index, Eastern Cooperative Oncology Group performance status, previous myocardial infarction and smoking history. These were converted into a risk-scoring model and internally validated using the validation set with an AUROC of 0.775. Conclusion: Despite a large dataset, AL proves difficult to predict using preoperative factors. The risk-scoring model for CN provides an internally validated tool to estimate a patient's risk preoperatively.

AB - Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to generate a risk scoring model for AL and CN after oesophagectomy. Methods: Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018–December 2018. Definitions for AL and CN were those set out by the Oesophageal Complications Consensus Group. Univariate and multivariate analyses were performed to identify risk factors for both AL and CN. A risk score was then produced for both AL and CN using the derivation set, then internally validated using the validation set. Results: This study included 2247 oesophagectomies across 137 hospitals in 41 countries. The AL rate was 14.2% and CN rate was 2.7%. Preoperative factors that were independent predictors of AL were cardiovascular comorbidity and chronic obstructive pulmonary disease. The risk scoring model showed insufficient predictive ability in internal validation (area under the receiver-operating-characteristic curve [AUROC] = 0.618). Preoperative factors that were independent predictors of CN were: body mass index, Eastern Cooperative Oncology Group performance status, previous myocardial infarction and smoking history. These were converted into a risk-scoring model and internally validated using the validation set with an AUROC of 0.775. Conclusion: Despite a large dataset, AL proves difficult to predict using preoperative factors. The risk-scoring model for CN provides an internally validated tool to estimate a patient's risk preoperatively.

UR - http://www.scopus.com/inward/record.url?scp=85190281598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85190281598&partnerID=8YFLogxK

U2 - 10.1016/j.ejso.2024.107983

DO - 10.1016/j.ejso.2024.107983

M3 - Article

AN - SCOPUS:85190281598

SN - 0748-7983

VL - 50

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 6

M1 - 107983

ER -

Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA). European Journal of Surgical Oncology. 2024 jun.;50(6):107983. doi: 10.1016/j.ejso.2024.107983